The Bodleian Libraries hold two copies of the first folio edition of Mr. William Shakespeare’s Comedies, Histories, & Tragedies (1623).
These have not always been in the Library, though; hear about the tangled history of the ‘Bodleian’ copy from Emma Smith, here.
And see the fully-digitised copy, shelfmarked Arch. G c.7, here.
And read here about the conservation effort to secure this volume.
See the list of digitized First Folios maintained by Sarah Werner at her blog Wynken de Worde http://sarahwerner.net/blog/digitized-first-folios/